dissoBOT :
The world’s first fully automated dissolution system with clip-on/off capability. Sequential cleaning, media dispensing and sample introduction. Suitable for Apparatus 2 (paddles) and Apparatus 1 (baskets). Internal tanks and external connections.
Advanced dissolution automation is built around world’s leading dissolution systems, like: Agilent 850-DS Dissolution Sampling Station and optional filtration module, Agilent 708-DS Dissolution Apparatus.
Working principle :
- Advanced automation is performed with the help of the latest technology in
collaborative robotics. The clip-on/off capability enables users to extend working cycles on their existing dissolution systems. There is no interference in the dissolution process and the clip-on procedure takes less than a minute. DissoBOT® system takes over the control of the dissolution apparatus and sampling station. Advanced dissolution automation technology of dissoBOT® performs fully automated sequential cycles of cleaning, media dispensing, and introduction of new dosage forms to the dissolution apparatus.
Highlights :
Clip-on/off platform with table-top collaborative robot
Sequential cleaning, media dispensing and samples introduction
Standard Agilent 708-DS Dissolution Apparatus and 850-DS Dissolution Sampling Station
Suitable for Apparatus 2 (paddles) and Apparatus 1 (baskets)
Internal tanks and external connections
System components :
Collaborative table-top rob
Cleaning tools, baskets and samples are moved by a small collaborative tabletop robot, perfect for light tasks and automated workbench scenarios. The robot’s safety system is approved and certified by TÜV (The German Technical Inspection Association).
Clip-on/off platform
Clip-on/off platform allows users to move the dissoBOT® around the laboratory. Two 47 L containers are installed into the dissoBOT platform. One is used to hold the dissolution media and the other for cleaning solution. External connections are also available for waste, DI water and media.
Cleaning procedure
The cleaning cycle is performed in two sequential steps. The first step is cleaning of paddles/basket shafts, evaporation covers, temperature probes and sampling cannulas with high-pressure nozzles. The second step of the cleaning procedure removes waste and cleans the vessels. Different cleaning cycles can be performed.
Dissolution process :
When dissoBOT® takes care of cleaning, media dispensing and dosage forms introduction, it is time for a dissolution process. The Dosage Delivery Module (DDM) is activated automatically. The dissolution itself is performed with standard 708-DS Dissolution Apparatus featuring a smooth-operating, motorized lift for reproducibility and integration with automated systems. Sampling is performed with an automated sampling manifold using the 850-DS Dissolution Sampling Station and optional filtration module. The system collects samples into test tubes, HPLC vials or well plates for subsequent analysis. Temperature is monitored with precise invessel monitoring AutoTemp. The individual vessel values may be documented initially, at each pre-programmed time point, and after the test has concluded.
Samples introduction :
Samples are introduced with an easy to use sample holder. 8 batches of 6 samples are individually stored at exact positions. For Apparatus 2 (paddles) configuration samples (dosage forms) are presented directly on DDM (Dosage Delivery Module) of Dissolution Apparatus 708-DS. For Apparatus 1 (baskets) configuration with a single set of baskets is used.
Media dispensing :
Media dispensing is done with unique dissoDOSE® technology. Fast, reliable and accurate volume dispensing is performed with direct volume measurement. Different speeds of pumping can be set to minimize the influence on foaming and degassed media.
Technical information :
Number of Working Positions
Up to 6 vessels
Number of Samples
Up to 8 batches of 6 samples
Number of Sampling Points
Up to 16
Internal Rinse Container
47 L (12.4 gal)
Internal Media Container
47 L (12.4 gal)
External Waste Container
100 L (26.4 gal) – optional
External Rinse Connection
Optional
External Media Connection
Optional
Media Dispense Principle
Volumetric media dispensing with dissoDOSE® technology
Media Dispensing Accuracy
< 1% (range from 400 mL to 1000 mL dispense)
Suitable for Methods
Apparatus 2 (paddles) and Apparatus 1 (baskets)
Media Types
Compatible with all typical dissolution media containing surfactants
Filtration Options
Cannula filters: 10, 35, and 70 μm; Filter plates: 0.45 μm
Media Replacement
Standard, up to 100% of sample removed
Sampling Accuracy
10 mL 2.5%
Sample Volume per Vial/Tube
0.1–14 mL (up to 28 mL with dual sample)
Sample Frequency
Method specific with minimum of 2 minutes
Evaporation
Less than 1% evaporative loss under specific conditions
Water Bath Temperature Range
Ambient +5 to 55 °C
Probe Accuracy
0.1 °C
Spindle Speed Range
10-250 RPM
Speed Accuracy
1% over 25 RPM, 2% 10-25 RPM
Speed Selection
Motorized drive
Spindle Shaft Material
Stainless steel
Dissolution Drive Unit Lift
Dosage Delivery Module (DDM), Autosampling, AutoTemp
dissoBOT
708-DS
850-DS
Advanced Dissolution Automation Module
Dissolution apparatus
Dissolution Sampling Station
Operating Height
190 cm
Operating Width
135 cm
Operating Depth
70 cm
Weight (Machine Dry)
80 kg
Width
62.2 cm
Operating Height
62.2 cm
Clearance Height
99.06 cm
Depth
59 cm
Weight
54.4 kg
Height
40 cm
Height with filter module
60 cm
Width
39 cm
Width with filter waste bin
48 cm
Depth
60 cm
Weight
27 kg